| Grey Friars v Windsor Home Park 13/11/1880 | View match | |
| Maidenhead v Old Harrovians 13/11/1880 | View match | |
| Reading FC v Hotspur 13/11/1880 | View match | |
| Reading Abbey v St Albans City 13/11/1880 | View match | |
| Rochester v Dreadnought 13/11/1880 | View match | |
| Romford v Reading Minster 13/11/1880 | View match | |
| Royal Engineers v Remnants 13/11/1880 | View match | |
| Upton Park v Mosquitoes 13/11/1880 | View match | |
| Weybridge Swallows v Henley FC 13/11/1880 | View match | |
| Herts Rangers v Barnes 16/11/1880 | View match | |
| Kildare v Acton 20/11/1880 | View match | |
| Old Foresters v Swifts 20/11/1880 | View match |