| Acton v Finchley 29/10/1881 | View match | |
| Astley Bridge v Turton 29/10/1881 | View match | |
| Blackburn Rovers FC v Blackburn Park Road 29/10/1881 | View match | |
| Darwen v Blackburn Olympic 29/10/1881 | View match | |
| Aston Villa FC v Nottingham Forest FC 05/11/1881 | View match | |
| Barnes v Rochester 05/11/1881 | View match | |
| Bootle v Blackburn Law 05/11/1881 | View match | |
| Grantham Town v Brigg Town 05/11/1881 | View match | |
| Hotspur v Union 05/11/1881 | View match | |
| Mosquitoes v Pilgrims 05/11/1881 | View match | |
| Old Carthusians v Esher Leopold 05/11/1881 | View match | |
| Old Etonians v Clapham Rovers 05/11/1881 | View match |