| Acton v Finchley 12/11/1881 | View match | |
| Eagley v Bolton Wanderers FC 12/11/1881 | View match | |
| Pilgrims v Mosquitoes 12/11/1881 | View match | |
| Reading Abbey v Woodford Bridge 12/11/1881 | View match | |
| Turton v Astley Bridge 12/11/1881 | View match | |
| Clapham Rovers v Old Etonians 19/11/1881 | View match | |
| Astley Bridge v Turton 19/11/1881 | View match | |
| Blackburn Rovers FC v Bolton Wanderers FC 19/11/1881 | View match | |
| Darwen v Accrington Stanley (1891) 26/11/1881 | View match | |
| Hanover United v Upton Park 26/11/1881 | View match | |
| Reading Abbey v Hotspur 26/11/1881 | View match | |
| Sheffield F.C v Sheffield Heeley 26/11/1881 | View match |