| Stafford Road v Grantham Town 16/12/1880 | View match | |
| Astley Bridge v Turton 18/12/1880 | View match | |
| Blackburn Rovers FC v The Wednesday 18/12/1880 | View match | |
| Reading FC v Swifts 18/12/1880 | View match | |
| Sheffield F.C v Darwen 18/12/1880 | View match | |
| Weybridge Swallows v Upton Park 18/12/1880 | View match | |
| Clapham Rovers v Swifts 08/01/1881 | View match | |
| Turton v The Wednesday 08/01/1881 | View match | |
| Old Etonians v Herts Rangers 05/02/1881 | View match | |
| Darwen v The Wednesday 05/02/1881 | View match | |
| Royal Engineers v Rangers (Glasgow) FC 09/02/1881 | View match | |
| Notts County FC v Aston Villa FC 12/02/1881 | View match |