| Old Harrovians v Maidenhead 20/11/1880 | View match | |
| Remnants v Royal Engineers 20/11/1880 | View match | |
| Windsor Home Park v Grey Friars 20/11/1880 | View match | |
| Derbyshire FC v Notts County FC 27/11/1880 | View match | |
| Hendon FC v Old Etonians 04/12/1880 | View match | |
| Nottingham Forest FC v Aston Villa FC 04/12/1880 | View match | |
| Royal Engineers v Pilgrims 09/12/1880 | View match | |
| Grantham Town v Stafford Road 11/12/1880 | View match | |
| Grey Friars v Maidenhead 11/12/1880 | View match | |
| Marlow FC v West End 11/12/1880 | View match | |
| Old Carthusians v Dreadnought 11/12/1880 | View match | |
| Reading Abbey v Acton 11/12/1880 | View match |