| Turton v Astley Bridge 26/11/1881 | View match | |
| Staveley v Grantham Town 28/11/1881 | View match | |
| Marlow FC v St Bartholomews 30/11/1881 | View match | |
| Maidenhead v Acton 03/12/1881 | View match | |
| Old Carthusians v Barnes 03/12/1881 | View match | |
| Old Foresters v Pilgrims 03/12/1881 | View match | |
| Reading Minster v Romford 03/12/1881 | View match | |
| Swifts v Old Harrovians 03/12/1881 | View match | |
| Turton v Bootle 03/12/1881 | View match | |
| Wednesbury Old Athletic v Small Heath 03/12/1881 | View match | |
| Notts County FC v Wednesbury Strollers 10/12/1881 | View match | |
| Darwen v Turton 17/12/1881 | View match |