| Swansea City FC v Millwall FC 15/09/2021 | £8.50 | |
| Manchester City FC v RB Leipzig 15/09/2021 | £7.50 | |
| Leicester City FC v SSC Napoli 16/09/2021 | £7.50 | |
| Sheffield Wednesday FC v Shrewsbury Town FC 18/09/2021 | £7.50 | |
| Gillingham FC v MK Dons (Milton Keynes Dons) 18/09/2021 | £7.50 | |
| Cardiff City FC v AFC Bournemouth 18/09/2021 | £8.00 | |
| Huddersfield Town FC v Nottingham Forest FC 18/09/2021 | £8.50 | |
| Peterborough United FC v Birmingham City FC 18/09/2021 | £7.50 | |
| Preston North End FC v West Bromwich Albion FC 18/09/2021 | £7.50 | |
| Northampton Town FC v Swindon Town FC 18/09/2021 | £8.50 | |
| Bristol Rovers FC v Leyton Orient FC 18/09/2021 | £7.50 | |
| Newport County AFC v Walsall FC 18/09/2021 | £7.50 |