| Manchester United FC v West Ham United FC 22/09/2021 | £5.99 | |
| Millwall FC v Leicester City FC 22/09/2021 | £7.50 | |
| Wolverhampton Wanderers FC v Tottenham Hotspur FC 22/09/2021 | £7.50 | |
| West Bromwich Albion FC v Queens Park Rangers FC 24/09/2021 | £7.50 | |
| Barrow AFC v Newport County AFC 24/09/2021 | £8.50 | |
| Hartlepool United v Exeter City FC 25/09/2021 | £7.50 | |
| Rochdale FC v Oldham Athletic FC 25/09/2021 | £7.50 | |
| AFC Bournemouth v Luton Town FC 25/09/2021 | £6.99 | |
| Nottingham Forest FC v Millwall FC 25/09/2021 | £5.99 | |
| Swansea City FC v Huddersfield Town FC 25/09/2021 | £9.50 | |
| Burton Albion FC v Lincoln City FC 25/09/2021 | £7.50 | |
| Ipswich Town FC v Sheffield Wednesday FC 25/09/2021 | £7.50 |