| Morecambe FC v Accrington Stanley FC 25/09/2021 | £8.50 | |
| Plymouth Argyle FC v Doncaster Rovers FC 25/09/2021 | £7.50 | |
| Brentford FC v Liverpool FC 25/09/2021 | £7.50 | |
| Leeds United FC v West Ham United FC 25/09/2021 | £7.50 | |
| Leicester City FC v Burnley FC 25/09/2021 | £7.50 | |
| Southampton FC v Wolverhampton Wanderers FC 26/09/2021 | £7.50 | |
| Arsenal FC v Tottenham Hotspur FC 26/09/2021 | £7.50 | |
| Crystal Palace FC v Brighton & Hove Albion FC 27/09/2021 | £7.50 | |
| Crystal Palace FC v Brighton & Hove Albion FC 27/09/2021 | £7.50 | |
| Burton Albion FC v Portsmouth FC 28/09/2021 | £7.50 | |
| Morecambe FC v Lincoln City FC 28/09/2021 | £8.50 | |
| Plymouth Argyle FC v Crewe Alexandra FC 28/09/2021 | £7.50 |